A serological test for tuberculosis.
نویسنده
چکیده
This paper describes an evaluation of the whole cell agglutination test for tuberculosist, carried out as Army Medical Directorate Research (AMDR) project 221. A !total of eighty-three cases, where the consultants were able to give a final diagnosis, are considered. The test was found to give inaccurate results in 39 per cent of cases under clinical investigation, also to show an 18 per cent false positive result in ante-natal patients who were established as not suffering from tuberculous disease. Apart from the erratic and unreliable results obtained with sera from women patients generally, the results presented here show that the test is too inaccurate to be of clinical value in early disease.
منابع مشابه
Evaluation of Human Serological Response to Recombinant TB10.4 Antigen of Mycobacterium tuberculosis
Introduction: Development of effective immunodiagnostic methods for detection of Mycobacterium tuberculosis infection is crucial. Serodiagnostic methods, based on antibody response to specific antigens could provide promising approaches for rapid, economical and easy to perform diagnostic tests which are crucial for tuberculosis (TB) control. In this study, the level of IgG antibody responses...
متن کاملPoor performance of a novel serological test for diagnosis of pulmonary tuberculosis in Bangui, Central African Republic.
We assessed the performance of a serological test for tuberculosis (SDHO Laboratories Inc., Canada) in our setting. Among 68 of 99 suspected pulmonary tuberculosis patients who were scored as having tuberculosis on the basis of Mycobacterium tuberculosis-positive culture, the sensitivity of the serological test was lower than that of sputum smear microscopic examination (20.6% versus 80.9%, res...
متن کاملSerological diagnosis of tuberculosis: a report of 12 months' clinical experience.
This study reports the use of an agglutination test as a routine diagnostic aid for tuberculosis. We have found this to be both useful and reliable in clinical practice. The overall reliability was greater than 90%, 13 false results being obtained in the 222 patients tested. False negatives (4) were less common than false positives (9). The major advantage of the test is its speed, serological ...
متن کاملتشخیص سریع سل به روش ایمونودات با استفاده از آنتی ژن 38 کیلودالتونی مایکوباکتریوم توبرکولوزیس
Background and Aim: Tuberculosis is an infectious disease with worldwide distribution. Based on WHO report one third of people are affected with mycobacterium tuberculosis. Today, the traditional bacteriological methods are only available using diagnostic methods for detection of tuberculosis. Innovation of a simple and efficient method for the diagnosis of tuberculosis is one of the most impor...
متن کاملWhy are inaccurate tuberculosis serological tests widely used in the Indian private healthcare sector? A root-cause analysis.
Serological tests for tuberculosis are inaccurate and WHO has recommended against their use. Although not used by the Revised National TB Control Programme (RNTCP), serodiagnostics are widely used in the private sector in India. A root-cause analysis was undertaken to determine why serological tests are so popular, and seven root causes were identified that can be grouped into three categories:...
متن کاملClinical evaluation of a serological assay using a monoclonal antibody (TB72) to the 38 kDa antigen of Mycobacterium tuberculosis.
We examined an enzyme-linked immunosorbent assay (ELISA) modification of a radioimmunoassay, using the TB72 monoclonal antibody, as a serological test for tuberculosis in a clinical setting. Sera were obtained from 238 patients with suspected pulmonary tuberculosis, 30 patients treated for tuberculosis, 28 contacts, and 480 random samples from inpatients. Antibody levels were measured as the di...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of the Royal Army Medical Corps
دوره 126 1 شماره
صفحات -
تاریخ انتشار 1980